Sandra Düzel

Biological age acceleration measured by DunedinPACE associates most consistently with cognitive decline in elderly individuals

This study finds that DunedinPACE, an epigenetic clock, most consistently associates with cognitive decline in older adults compared to other DNAm clocks and telomere length.

Vulnerability to memory decline in aging. A mega-analysis of structural brain change.

This study investigates the relationship between brain atrophy and memory decline in aging using longitudinal data, finding a nonlinear association that intensifies with age and is influenced by APOE ε4 carriership.

Blood-based multivariate methylation risk score for cognitive impairment and dementia

The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.

Genome-wide QTL mapping across three tissues highlights several Alzheimer's and Parkinson's disease loci potentially acting via DNA methylation

The paper maps DNA methylation quantitative trait loci (meQTL) in three tissues and uses Mendelian randomization to link DNAm to Alzheimer's and Parkinson's disease risk.

The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance

This study examines the relationship between dopaminergic and noradrenergic brain region integrity and late-life memory performance using longitudinal MRI data.

Age Differences in Diffusivity in the Locus Coeruleus and its Ascending Noradrenergic Tract

The paper examines age-related differences in fractional anisotropy in the locus coeruleus and its ascending noradrenergic tract using diffusion-weighted MRI across three datasets.

Vamos en bici: Study protocol of an investigation of cognitive and neural changes following language training, physical exercise training, or a combination of both

This study investigates how language training, physical exercise, or their combination affects brain structure, cognitive performance, and psychosocial functioning in older adults.

Individual variations in Brain age relate to early life factors more than to longitudinal brain change

This study finds that adult brain age is more influenced by early life factors like birth weight and polygenic scores than by longitudinal brain decline.

Education and income show heterogeneous relationships to lifespan brain and cognitive differences across European and US cohorts

The paper examines how education and income relate to brain and cognitive differences across European and US cohorts, finding heterogeneous effects and stronger associations in US samples.

Self-Reported Sleep Relates to Microstructural Hippocampal Decline in β-Amyloid Positive Adults Beyond Genetic Risk

This study finds that worse self-reported sleep relates to faster hippocampal microstructural decline in β-amyloid positive adults, independent of genetic risk.

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's Disease

The paper identifies asymmetric thinning of the cerebral cortex across aging and Alzheimer's Disease, showing that the initially thicker hemisphere thins faster, with this pattern replicated across multiple cohorts.

Locus coeruleus MRI contrast is associated with cortical thickness in older adults

The paper examines the relationship between locus coeruleus MRI contrast and cortical thickness in older and younger adults, finding a positive association in specific brain regions.

Hippocampal and parahippocampal grey matter structural integrity assessed by multimodal imaging is associated with episodic memory in old age

The paper introduces a multimodal imaging approach to assess grey matter structural integrity in older adults and finds it correlates with episodic memory, particularly in men.

The genetic organization of subcortical volumetric change is stable throughout the lifespan

This paper identifies stable developmental clusters of subcortical volumetric change across the lifespan and shows genetic organization within these clusters.

Self-reported sleep problems are related to cortical thinning in aging but not memory decline and amyloid-β accumulation - results from the Lifebrain consortium

The paper examines the relationship between self-reported sleep parameters and cortical thinning in aging, finding associations with specific brain regions but not with memory decline or amyloid-β accumulation.

Self-reported sleep relates to hippocampal atrophy across the adult lifespan - results from the Lifebrain consortium

The paper examines how self-reported sleep relates to hippocampal atrophy across adulthood using data from the Lifebrain consortium and UK Biobank, finding that worse sleep is linked to faster hippocampal volume loss over time.

Hippocampal subfields and limbic white matter jointly predict learning rate in older adults

This study shows that limbic white matter microstructure and hippocampal subfield volumes together predict verbal learning rates in older adults, with an interaction effect observed.

Higher rostral locus coeruleus integrity is associated with better memory performance in older adults

Efficient small-world and scale-free functional brain networks at rest using k-nearest neighbors thresholding

This paper compares k-nearest neighbors (kNN) and density threshold methods for constructing brain networks from resting state fMRI, finding kNN produces more efficient and resilient networks with small-world and scale-free properties.

Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans

The paper examines the relationship between dietary tyrosine intake, brain functional connectivity, and working memory performance in healthy elderly individuals, finding negative correlations between tyrosine intake and striatum-prefrontal cortex connectivity.