Lars H Nyberg

Feature-specific environmental contributions to human cortical architecture revealed by twin brainprints

This study identifies how different environmental factors affect cortical architecture in twins, showing persistent early life effects and training-induced changes in adulthood.

Global brain maintenance predicts well-preserved cognitive function: A pooled analysis of three longitudinal population-based Swedish cohorts

This study shows that maintaining brain integrity through aging is linked to better cognitive function and slower decline, with lifestyle factors like lower cardiovascular risk and no diabetes playing a role.

Stable episodic memory and high education do not influence the rate of Alzheimer's disease pathology as measured by plasma p-tau217

The paper examines whether stable episodic memory or high education affects Alzheimer's disease pathology measured by plasma p-tau217, finding no such association.

Punctuated memory change: The temporal dynamics and brain basis of memory stability in aging

The paper identifies a subset of older adults with stable memory performance over time, linking this stability to brain structure and showing it is often transient rather than consistent.

Stable Individual Differences Dominate Adult Brain Volume Variation Until Later Life

This study examines how brain volume differences in adults are stable from young adulthood or change with age, using MRI data from 8,311 individuals.

Vulnerability to memory decline in aging. A mega-analysis of structural brain change.

This study investigates the relationship between brain atrophy and memory decline in aging using longitudinal data, finding a nonlinear association that intensifies with age and is influenced by APOE ε4 carriership.

Two long-axis dimensions of hippocampal cortical integration support memory function across the adult lifespan

The paper shows two hippocampal integration dimensions persist across adulthood, relate to memory and dopamine distribution, and decline with age.

Reliability of structural brain change in cognitively healthy adult samples.

This study assesses the reliability of structural brain change in cognitively healthy adults over time, finding that longer follow-up periods significantly improve reliability compared to increasing observation frequency.

Brain-Cognitive Gaps in relation to Dopamine and Health-related Factors: Insights from AI-Driven Functional Connectome Predictions

The paper uses deep learning to predict cognitive performance from functional connectomes during different brain states and identifies the brain-cognition gap as a dopamine-related marker of cognitive vulnerability.

Altered empathy processing in frontotemporal dementiaA task-based fMRI study

This study uses fMRI to examine empathy processing in bvFTD patients and controls, finding reduced BOLD signal in key regions and altered connectivity patterns.

Dopamine D1-receptor Organization Contributes to Functional Brain Architecture

The paper shows that dopamine D1 receptor organization in humans aligns with a unimodal-to-transmodal functional gradient and influences network differentiation and connectivity.

Accelerated brain change in healthy adults is associated with genetic risk for Alzheimer's disease and uncovers adult lifespan memory decline

The paper shows that higher genetic risk for Alzheimer's disease is linked to faster brain volume loss and memory decline in healthy adults.

Is short sleep bad for the brain? Brain structure and cognitive function in short sleepers

The paper investigates the effects of short sleep on brain structure and cognitive function, finding that short sleepers without daytime tiredness have larger brain volumes but slightly lower cognitive scores.

Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.

Brain aging differs with cognitive ability regardless of education

The paper investigates how general cognitive ability relates to cortical brain volume changes over time, finding associations with both brain reserve and maintenance mechanisms.

Bi-phasic patterns of age-related differences in dopamine D1 receptors across the adult lifespan

The paper identifies a bi-phasic pattern of age-related dopamine D1 receptor decline, with distinct functional consequences before and after 40 years of age.

Dynamic regulation of neural variability during working memory reflects dopamine, functional integration, and decision-making

This study examines how neural variability during working memory is regulated by dopamine, functional integration, and decision-making using PET and fMRI data.

Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

The paper examines age-related variations in cortical thickness across different life stages using gene expression data from a large neuroimaging dataset.

Sleep duration and brain structure - phenotypic associations and genotypic covariance

This study examines the relationship between sleep duration and brain structure using MRI data, finding that 6.8 hours of sleep is associated with the most favorable brain outcomes, with genetic analyses suggesting homeostatic regulation of sleep duration.

Individual variations in Brain age relate to early life factors more than to longitudinal brain change

This study finds that adult brain age is more influenced by early life factors like birth weight and polygenic scores than by longitudinal brain decline.

Sex-specific effects of polygenic risk for schizophrenia on lifespan cognitive functioning in healthy individuals

This study examines sex-specific effects of polygenic risk for schizophrenia on cognitive functioning across the lifespan in healthy individuals, finding male-specific associations.

Education and income show heterogeneous relationships to lifespan brain and cognitive differences across European and US cohorts

The paper examines how education and income relate to brain and cognitive differences across European and US cohorts, finding heterogeneous effects and stronger associations in US samples.

Self-Reported Sleep Relates to Microstructural Hippocampal Decline in β-Amyloid Positive Adults Beyond Genetic Risk

This study finds that worse self-reported sleep relates to faster hippocampal microstructural decline in β-amyloid positive adults, independent of genetic risk.

Effects on brain activity after creative mathematical reasoning when considering individual differences in cognitive ability

The paper investigates brain activity differences after creative mathematical reasoning versus algorithmic reasoning, finding higher activity in key regions with CMR, independent of cognitive ability and performance.

Dopamine and reward-related vigor in younger and older human participants

The paper examines how reward and dopamine affect vigor in younger and older humans, finding similar reward effects across age groups with weak dopamine receptor involvement.

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's Disease

The paper identifies asymmetric thinning of the cerebral cortex across aging and Alzheimer's Disease, showing that the initially thicker hemisphere thins faster, with this pattern replicated across multiple cohorts.

The functional foundations of episodic memory remain stable throughout the lifespan

This study investigates whether the functional foundations of episodic memory encoding remain consistent across the lifespan, finding continuity rather than late-life specificity.

The genetic architecture of human brainstem structures and their involvement in common brain disorders

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

The genetic organization of subcortical volumetric change is stable throughout the lifespan

This paper identifies stable developmental clusters of subcortical volumetric change across the lifespan and shows genetic organization within these clusters.

Self-reported sleep problems are related to cortical thinning in aging but not memory decline and amyloid-β accumulation - results from the Lifebrain consortium

The paper examines the relationship between self-reported sleep parameters and cortical thinning in aging, finding associations with specific brain regions but not with memory decline or amyloid-β accumulation.