α-Synuclein acts as a cholesteryl-ester sensor on lipid droplets regulating organelle size and abundance.
Reeba Susan Jacob, Alessandro Dema, Hélène Chérot, Calvin Dumesnil, Shira Cohen, Hadas Sar Shalom, Nitzan Rimon, Odelia Sibony-Nevo, Gilad Beck, Elena Ainbinder, Heimo Wolinski, Karin Athenstaedt, François‐Xavier Theillet, Abdou Rachid Thiam, Philipp Selenko
This study shows α-Synuclein binds lipid droplets, senses cholesteryl-ester, regulates organelle size and abundance, and links its dysfunction to neurodegenerative diseases.
bioRxiv · Jun 19, 2024 · PreprintCell Biology