Author

François‐Xavier Theillet

Centre National de la Recherche ScientifiqueORCID 0000-0002-3264-210XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Hélène Chérot· 2 shared Abdou Rachid ThiamiD· 1 shared Alessandro DemaiD· 1 shared Anastasiia Skobelkina· 1 shared Angelos ConstantinouiD· 1 shared Aura CarreiraiD· 1 shared Calvin DumesniliD· 1 shared Claire T. FrieliD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Hélène Chérot

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

In-cell residue-resolved NMR of micromolar α-synuclein and tau at 310K

Hélène Chérot, Théophile Pred’homme, Robert Thaï, Frédéric Théodoro, Florence Anne Castelli, François‐Xavier Theillet

This study uses in-cell NMR at 310K to analyze α-synuclein and tau conformations and interactions in live human cells at micromolar concentrations.

Journal of the American Chemical Society · Dec 4, 2025Peer-reviewedBiochemistry

KIF2C-induced nuclear condensation concentrates PLK1 and phosphorylated BRCA2 at the kinetochore microtubules in mitosis

Anastasiia Skobelkina, Manon Julien, Sylvain Jeannin, Simona M. Miron, Tom Egger, Rady Chaaban, Guillaume Bouvignies, Emile Alghoul, Rania Ghouil, Claire T. Friel, Didier Busso, Juan C. Cañas, François‐Xavier Theillet, Romain Le Bars, Aura Carreira, , Sophie Zinn‐Justin

The paper shows KIF2C forms condensates during mitosis that concentrate PLK1 and phosphorylated BRCA2 at kinetochore microtubules, enhancing their kinase activity and attachment stability.

Nucleic Acids Research · Jun 6, 2025Peer-reviewedCell Biology

α-Synuclein acts as a cholesteryl-ester sensor on lipid droplets regulating organelle size and abundance.

Reeba Susan Jacob, Alessandro Dema, Hélène Chérot, Calvin Dumesnil, Shira Cohen, Hadas Sar Shalom, Nitzan Rimon, Odelia Sibony-Nevo, Gilad Beck, Elena Ainbinder, Heimo Wolinski, Karin Athenstaedt, François‐Xavier Theillet, Abdou Rachid Thiam, Philipp Selenko

This study shows α-Synuclein binds lipid droplets, senses cholesteryl-ester, regulates organelle size and abundance, and links its dysfunction to neurodegenerative diseases.

bioRxiv · Jun 19, 2024 · PreprintCell Biology