Raffaele M Iannuzzi

The paper identifies ADD3 as a regulator of glioblastoma stem cell morphology and tumor-tumor connections, showing its role in proliferation and survival.

This study benchmarks seven computational methods for correcting CN and proximity biases in CRISPR-Cas9 screens, finding AC-Chronos and CRISPRcleanR perform best in different scenarios.

The paper provides a dataset and R package to benchmark CRISPR-Cas9 screening pipelines using HT-29 cells and a commercial guide RNA library.