Nereo Kalebic

Stem cell morphology defines functional heterogeneity and therapeutic vulnerabilities in glioblastoma

This paper identifies three glioblastoma stem cell morphoclasses using CellShape-seq, showing distinct functions and therapeutic vulnerabilities.

Lysergic acid diethylamide reverses aging- and neurodegeneration-associated brain transcriptional programs

This study shows that LSD induces gene expression patterns opposing aging and neurodegeneration in the brain, suggesting potential therapeutic effects through transcriptional reversal.

Human basal radial glia morphotypes are transcriptionally distinct and exhibit different cell fate determination

The paper identifies transcriptionally distinct morphotypes of human basal radial glia and links their morphology, gene expression, and cell fate.

Adducins regulate morphology and fate of neural progenitors during neocortical neurogenesis

This study shows adducins regulate proliferation and fate of neural progenitors in mouse, ferret, and human neocortex, affecting neurogenesis.

Human-specific morphoregulatory signatures in basal radial glia characterize neocortex evolution

This study identifies human-specific morphoregulatory signatures in basal radial glia that drive neocortex evolution through comparative chromatin and transcriptional profiling.

Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor-tumor connections

The paper identifies ADD3 as a regulator of glioblastoma stem cell morphology and tumor-tumor connections, showing its role in proliferation and survival.

DOT1L activity affects cell lineage progression in the developing brain by controlling metabolic programs

This study shows that DOT1L activity regulates AP lineage progression in the developing mouse neocortex by controlling metabolic programs and gene expression.

Extracellular matrix-inducing Sox9 orchestrates basal progenitor proliferation and gliogenesis in developing neocortex

This study shows Sox9 regulates basal progenitor proliferation and gliogenesis in the developing neocortex through ECM induction and integrin signaling.

YAP activity is necessary and sufficient for basal progenitor abundance and proliferation in the developing neocortex

This study shows YAP activity is necessary and sufficient for basal progenitor proliferation and abundance in the developing neocortex, linking it to neocortical expansion during evolution.

Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

This study shows that human-specific ARHGAP11B increases proliferative basal radial glia and expands the neocortex in developing ferrets.