Ichcha Manipur

Design and interpretation of eQTL-GWAS colocalisation studies: lessons from a large-scale evaluation

The paper evaluates eQTL-GWAS colocalisation studies, finding that 34-50% of GWAS hits colocalise, with trade-offs between granularity, sample size, and colocalisation detection.

Benchmark data and software for assessing genome-wide CRISPR-Cas9 screening pipelines

The paper provides a dataset and R package to benchmark CRISPR-Cas9 screening pipelines using HT-29 cells and a commercial guide RNA library.

CoPheScan: phenome-wide association studies accounting for linkage disequilibrium

CoPheScan improves PheWAS by accounting for linkage disequilibrium, identifying causal associations and reducing false positives in genetic variant analyses.

Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor

This study identifies TBXT's role in early posterior regionalisation of human neural crest cells through chromatin remodelling and WNT signalling.

Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives

This study identifies signalling pathways that guide the generation of posterior ventral spinal cord motor neurons from human pluripotent stem cells.