Maria Inês Alvelos

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

RedRibbon is a rank-rank hypergeometric overlap method for comparing gene and transcript expression signatures, showing accuracy and efficiency on large datasets.

The paper identifies stable reference genes for normalizing gene expression in human pancreatic beta cells under stress conditions using RNA-seq and qPCR validation.

This study shows that pro-inflammatory cytokines reveal plasticity in β-cell regulatory landscapes and identify T1D-associated variants disrupting cytokine-responsive enhancers.