Leif Østergaard

The paper shows that female mice have higher cortical blood flow and reduced oxygen extraction fraction in middle age, with molecular and structural differences in white matter and microglial reactivity, without differences in systemic markers.

The paper shows that pial arteries in awake mice bend with each heartbeat, displacing walls more than three times the pulse-related dilatation, while veins show minimal movement.

This study introduces a new method to measure microvascular pulsatility in mice and shows that anaesthesia alters pulsatility patterns, affecting the assessment of brain function.

This study shows carbonic anhydrase inhibitors prevent capillary flow issues in a mouse model of early Alzheimer's disease before symptoms appear.

This study uses diffusion kurtosis MRI to show that anesthesia reduces mean diffusivity and kurtosis in both gray and white matter of mice, suggesting increased extracellular space volume.

This study shows that microvascular flow disturbances increase in the ischemic penumbra after middle cerebral artery occlusion in rats, suggesting they are a key factor in tissue outcome.

This study tests FDA-approved carbonic anhydrase inhibitors in a transgenic AD model, finding they reduce amyloid beta pathology and improve cognition by enhancing cerebrovascular health and glial function.

The paper presents a semi-automatic method for 3D reconstruction of mitochondria and cristae from 2D EM images, offering more accurate characterization of mitochondrial ultrastructure than 2D approaches.

The paper measures capillary flow and oxygenation in cortical layers of awake mice, finding homogenization of oxygen delivery and increased extraction in layer IV.

The paper compares five classification methods for identifying high-risk infarction tissue in ischemic stroke using MRI data, finding no significant difference in precision-recall performance.