Léonard Hérault

SuperCell2.0 constructs multimodal metacell atlases from blood and tumor samples, identifying interferon-primed monocytes and macrophages with improved inter-modality consistency.

SuperSpot reduces spatial transcriptomic data size and noise by grouping similar spots into metaspots using graph-based clustering.

The paper reviews metacell applications in single-cell genomics, provides a tutorial, and introduces a pipeline for metacell construction and analysis.

This study introduces STACAS v2, a semi-supervised method for integrating scRNA-seq data that outperforms existing methods by preserving biological variability using cell type annotations.

The paper develops a Boolean network model of early hematopoiesis aging using scRNA-seq data and literature, identifying key regulatory changes in aged HSCs.

The paper analyzes single-cell RNA-seq data from young and aged mouse HSCs to show delayed differentiation and cell cycle imbalance in aged HSCs.

This study identifies NEUROD2 mutations linked to ASD and intellectual disability, showing their role in cortical development and function through mouse models.

The paper identifies PLZF's role in limiting enhancer activity during hematopoietic progenitor aging by targeting H3K27ac.