David E. Sanin

This study shows mitochondrial dysfunction accelerates aging by disrupting gut microbiota structure and inducing immune dysregulation and inflammation through metabolic reprogramming.

This study shows IL-33 promotes the development of tissue-resident-like Th2 cells through arginine metabolism and mTORC1 activation, with transcriptional changes linked to tissue integration.

This study shows that different modes of macrophage cell death affect wound healing outcomes, with necroptosis impairing repair and apoptosis promoting better tissue recovery.

SpotGraphs provides a flexible R package for directly interacting with spatially resolved transcriptomic data through graph analysis, offering tools for quality filtering and adjacency editing.

The paper shows that cysteine in CD8+ T cells is partitioned into glutathione and FeS-cluster synthesis, supporting effector functions and proliferation, respectively.

The paper identifies transcriptional shifts by analyzing missing data patterns in single-cell transcriptomes, revealing a metabolic shift in D. discoideum.

This study identifies high-motility tumor-associated monocytes (TAMos) that drive macrophage infiltration and cancer cell proliferation via IL-6 and MAPK pathways, suggesting IL-6 as a therapeutic target.