Rhaissa Calixto Vieira

Parthenolide boosts megakaryocyte maturation and restores platelet responses in Wiskott Aldrich syndrome

This study identifies parthenolide as a potential therapy for Wiskott-Aldrich syndrome by enhancing megakaryocyte maturation and platelet function in both cell and mouse models.

A systematic approach to understanding how patient variants affect the activity of Wiskott-Aldrich syndrome protein

This paper systematically analyzes how patient variants affect WASp activity, identifying gain-of-function and loss-of-function variants through structural and functional assays.

AID facilitates TET2 demethylation of Irf4 for plasma cell fate in germinal center B cells

This study shows AID deficiency in B cells leads to reduced IRF4 expression and impaired plasma cell differentiation due to disrupted TET2-mediated demethylation of the Irf4 promoter.