Fred S. Lamb

This study identifies N-terminal and transmembrane domain regions in LRRC8C and LRRC8D channels that mediate oxidant-dependent current activation and inhibition.

This study shows that knocking out LRRC8A in vascular smooth muscle cells reduces superoxide influx, inflammation, senescence, and atherosclerosis.

This study shows that LRRC8A knockout in vascular smooth muscle cells protects against AngII-induced vascular dysfunction and preserves BP dipping in hypertension.