H. Joseph Yost

This study uses AI to show that genome sequencing can predict adverse outcomes after congenital heart defect surgery by identifying damaging genotypes in specific genes.

EpiFlow enables multiparametric analysis of histone PTMs in whole cells using spectral flow cytometry, revealing chromatin state variations in neural progenitor cells.

This paper presents an informatic method to identify germline de novo mutations in family trios using consensus across variant callers, achieving high precision and recall.

SLALOM rapidly generates CRISPR-Cas9 sgRNA libraries from DNA in under 3 hours, enabling efficient and cost-effective library synthesis for various biological applications.

This study shows that Syndecan 2 is essential for hematopoietic lineage specification, immune function, and infection resolution in zebrafish.

This study shows that inhibiting Notch signaling rescues cardiovascular defects in zebrafish with Kmt2d mutations, linking Kmt2d to vasculogenesis in Kabuki Syndrome.

This study shows that human amniocytes can be reprogrammed into cardiomyocytes via iPSC intermediates, but direct reprogramming fails due to transcriptional repression.

This study shows that loss of embryonic neural crest cardiomyocytes in zebrafish leads to adult hypertrophic cardiomyopathy with altered heart structure and function.

The paper identifies Nkx2.5-dependent DNA methylation changes in zebrafish hearts and links them to cis-regulatory elements involved in cardiac development.