Timothy L. Mosbruger

A Rare T-Cell Factor 4 Lineage-negative Epithelial Stem Cell Supports Wound Repair and APC-deletion-induced Colon Tumorigenesis

The paper identifies a rare Tcf4 lineage-negative stem cell population in the colon that contributes to wound repair and colon tumorigenesis when Apc is deleted.

Multi-omics Differential Inference for Functional Interpretation (MoDIFI): A Statistical Framework to Prioritize Cell Lines for Neurodevelopmental Variants

The paper develops MoDIFI, a Bayesian framework to prioritize cell lines and regulatory regions for testing noncoding variants associated with neurodevelopmental disorders.

Ancestry adjustment improves genome-wide estimates of regional intolerance

This study shows that adjusting for ancestry improves genome-wide estimates of regional intolerance by incorporating demographic history, leading to better variant classification.

Improved detection of evolutionary selection highlights potential bias from different sequencing strategies in complex genomic-regions

The paper develops a Bayesian method to detect balancing selection across different sequencing technologies and identifies novel genes under selection in complex genomic regions.

AnthOligo: Automating the design of oligonucleotides for capture/enrichment technologies

AnthOligo automates the design of oligonucleotides for genomic capture technologies by optimizing parameters like Tm and ΔG while minimizing primer dimers.

Nkx2.5-dependent alterations of the embryonic heart DNA methylome identify novel cis-regulatory elements in cardiac development

The paper identifies Nkx2.5-dependent DNA methylation changes in zebrafish hearts and links them to cis-regulatory elements involved in cardiac development.