Colin T. Maguire

This paper develops CD38KO/CD38-CAR γδT cells for T cell malignancies, showing they effectively target T-ALL without causing fratricide or GvHD.

REMEDY enables efficient repair of heterozygous mutations in human and mouse cells without exogenous donor DNA by using CRISPR-induced DSBs and HDR enhancers.

The paper describes the generation and characterization of patient-derived iPSC lines and isogenic pairs for Ogden syndrome, including CRISPR corrections and X-chromosome screening.

This study shows that human amniocytes can be reprogrammed into cardiomyocytes via iPSC intermediates, but direct reprogramming fails due to transcriptional repression.