Author

A.G. Murachelli

The Netherlands Cancer InstituteORCID 0000-0003-2968-8972Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Farid El OualidiD· 1 shared Titia K. SixmaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperBiochemistry

Farid El OualidORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedAug 11, 2026

A ubiquitin chain-feeding mechanism for BRCA1-A

A.G. Murachelli, Farid El Oualid, Titia K. Sixma

This study identifies a chain-feeding mechanism in BRCA1-A that explains its preference for long K63-linked ubiquitin chains through avidity and processivity.

DOI 10.1038/s41467-026-75797-w

cryo-EMexperimental assay

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