Author

Farid El Oualid

The Netherlands Cancer InstituteORCID 0000-0002-4447-9960Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Titia K. SixmaiD· 2 shared A.G. MurachelliiD· 1 shared Alexander FishiD· 1 shared Jan SakoltchikiD· 1 shared Kaustav MajumderiD· 1 shared Niels KeijzeriD· 1 shared Nina van LiliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

Titia K. SixmaORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedAug 11, 2026

A ubiquitin chain-feeding mechanism for BRCA1-A

A.G. Murachelli, Farid El Oualid, Titia K. Sixma

This study identifies a chain-feeding mechanism in BRCA1-A that explains its preference for long K63-linked ubiquitin chains through avidity and processivity.

DOI 10.1038/s41467-026-75797-w

cryo-EMexperimental assay

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedJul 30, 2025

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that enriches for monoubiquitinated PCNA

Niels Keijzer, Jan Sakoltchik, Kaustav Majumder…·Titia K. Sixma

This study shows USP1/UAF1 cleaves K48 and K63-linked ubiquitin chains on PCNA via exo-cleavage, preferentially enriching monoubiquitinated PCNA, which may influence DNA damage tolerance pathway choice.

14 citationstop 5%

experimental assaychromatin & epigenetic regulation

𝕏 PostBluesky