Author

Titia K. Sixma

The Netherlands Cancer InstituteORCID 0000-0001-6180-0632Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Farid El OualidiD· 2 shared A.G. MurachelliiD· 1 shared Alex PinesiD· 1 shared Alexander FishiD· 1 shared Anisha R. Ramadhin· 1 shared Anita P. T. SalmazoiD· 1 shared Anja RaamsiD· 1 shared Camila Gonzalo-HanseniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

Farid El OualidORCID

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3 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedAug 11, 2026

A ubiquitin chain-feeding mechanism for BRCA1-A

A.G. Murachelli, Farid El Oualid, Titia K. Sixma

This study identifies a chain-feeding mechanism in BRCA1-A that explains its preference for long K63-linked ubiquitin chains through avidity and processivity.

DOI 10.1038/s41467-026-75797-w

cryo-EMexperimental assay

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BiochemistryNature CommunicationsPeer-reviewedJul 30, 2025

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that enriches for monoubiquitinated PCNA

Niels Keijzer, Jan Sakoltchik, Kaustav Majumder…·Titia K. Sixma

This study shows USP1/UAF1 cleaves K48 and K63-linked ubiquitin chains on PCNA via exo-cleavage, preferentially enriching monoubiquitinated PCNA, which may influence DNA damage tolerance pathway choice.

14 citationstop 5%

experimental assaychromatin & epigenetic regulation

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Molecular BiologybioRxivPreprintJul 22, 2024

STK19 drives Transcription-Coupled Repair by stimulating repair complex stability, Pol II ubiquitylation and TFIIH recruitment

Anisha R. Ramadhin, Shun-Hsiao Lee, Di Zhou…·Jurgen A. F. Marteijn

This study identifies STK19 as a critical factor in transcription-coupled nucleotide excision repair by stabilizing the repair complex and promoting Pol II ubiquitylation and TFIIH recruitment.

3 citations

humanDNA methylation

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