Florence M. Cammas

This study shows PKA inhibits TRIM28-chromatin binding in ovarian granulosa cells, disrupting ovarian identity through SUMOylation dysregulation.

The paper shows that loss of HP1α, but not HP1β, increases chromosomal breaks and fragile site activity under replication stress.

This study identifies TRIM28's role in preserving ovarian identity by stabilizing lineage-specific transcription factor hubs rather than through H3K9me3-dependent heterochromatin.

This study shows that HP1 interacts with the RNA exosome, affecting RNA degradation and transcriptional programs in liver cells, with implications for cancer biology.

This study shows that inhibiting SUV4-20H enzymes enhances the effectiveness of TOP2 poisons in prostate cancer by increasing DNA damage and impairing repair mechanisms.

This study identifies TRIM28's role in preventing female-to-male sex reversal in the adult mouse ovary by maintaining the ovarian pathway through SUMOylation.