Natalie Bucheimer Collins

The paper identifies clustered structural variant hotspots in osteosarcoma, linking them to oncogenic addiction and plasticity through transcriptional changes and clinical detectability.

This study identifies a loss of osteoblastic lineage fidelity in metastatic osteosarcoma through single-nucleus RNA sequencing, linking it to disease progression and potential therapeutic targets.

This study uses plasma cfDNA fragmentomics to distinguish malignant, pre-malignant, and non-malignant NF1-associated peripheral nerve sheath tumors.

The paper develops a toolbox for scRNA-Seq and snRNA-Seq of fresh and frozen human tumors, testing it across eight tumor types and optimizing protocols for different tissue characteristics.