Author

Caroline B. M. Porter

Broad InstituteORCID 0000-0001-8294-5232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 4 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 6 Research Focus:differential expression· 4 Assay:scRNA-seq· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Assay:spatial transcriptomics· 3 Research Focus:clustering· 2

Frequent Co-Authors

Orr AshenbergiD· 5 shared Toni Marie DeloreyiD· 4 shared Aviv RegeviD· 3 shared Deborah Tan HungiD· 3 shared Devan PhillipsiD· 3 shared Jason ReevesiD· 3 shared Joseph BeechemiD· 3 shared Joshua GouldiD· 3 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersGenomics

Orr AshenbergORCID

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Author profile →

6 papers

Recent·Most cited

Type 1 immunity linked to CMV exposure improves long-term survival in sepsis without shock

Wei Qi, Nuzat Zaman, Alexis Rooney, Caroline B. M. Porter, Konstantinos Boulias, Sarah Naz‐McLean, Joshua Pickard, Marla Glean, Ndongwa Pemba, Kastin Pan, Shilei Li, Hannah H. Laibinis, Con Moran, Erin Connolly, Grace Valentine, , Jacques Deguine

The paper links CMV exposure-associated Type 1 immunity to improved long-term survival in sepsis without shock, but not in septic shock.

bioRxiv · Oct 19, 2026 · PreprintImmunology

Population-scale multiome immune cell atlas reveals complex disease drivers

Masahiro Kanai, Toni Marie Delorey, Jarno K. Honkanen, Rodosthenis S. Rodosthenous, Julianna Juvila, Shane M. Murphy, Isabella Teixeira-Soldano, Hee Seung Hwang, Juha M Karjalainen, Jussi Halonen, Georgia Panagiotaropoulou, Yuanxiang Zhang, Cristin Aubin, Eric Chen, Kosaku Nanki, , Ramnik J. Xavier

The paper uses population-scale single-nucleus ATAC-seq and RNA-seq to identify regulatory variants and their disease associations in immune cells.

medRxiv · Nov 25, 2025 · PreprintGenetic & Genomic Medicine

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

Yered H. Pita-Juárez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C. Melms, Sebastian Niezen, Toni Marie Delorey, Adam L. Essene, Olga Rachel Brook, Deepti B. Pant, Disha Skelton-Badlani, Pourya Naderi Yeganeh, Pinzhu Huang, Liuliu Pan, TYLER D. HETHER, Tallulah S. Andrews, , Ioannis S. Vlachos

This study creates a single-nucleus and spatial transcriptomic atlas of the COVID-19 liver, revealing cellular and functional disruptions associated with organ damage.

Genome biology · Mar 14, 2025Peer-reviewedGenomics

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

Toni Marie Delorey, Carly G.K. Ziegler, Graham Heimberg, Rachelly Normand, Yiming Yang, Åsa Segerstolpe, Domenic Abbondanza, Stephen J. Fleming, Ayshwarya Subramanian, Daniel T. Montoro, Karthik A. Jagadeesh, Kushal K. Dey, Pritha Sen, Michal Slyper, Yered H. Pita-Juárez, , Alexandra–Chloé Villani

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.

bioRxiv · Feb 25, 2021 · PreprintGenomics

Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment

William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Payman Yadollahpour, Rahul R. Mohan, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Orr Ashenberg, Samouil L. Farhi, Denis Schapiro, Jason Reeves, Daniel R. Zollinger, George M. Eng, Jason M. Schenkel, , Aviv Regev

This study uses single-nucleus and spatial transcriptomics to analyze pancreatic cancer before and after neoadjuvant treatment, revealing changes in cell states and immune infiltration that may inform therapy.

bioRxiv · Aug 25, 2020 · PreprintGenomics

A single-cell and single-nucleus RNA-seq toolbox for fresh and frozen human tumors

Michal Slyper, Caroline B. M. Porter, Orr Ashenberg, Julia Waldman, Eugene Drokhlyansky, Isaac Wakiro, Christopher S. Smillie, Gabriela Smith-Rosario, Jingyi Wu, Danielle Ashley Dionne, Sébastien Vigneau, Judit Jané‐Valbuena, Timothy L. Tickle, Sara Napolitano, Mei-Ju Su, , Aviv Regev

The paper develops a toolbox for scRNA-Seq and snRNA-Seq of fresh and frozen human tumors, testing it across eight tumor types and optimizing protocols for different tissue characteristics.

Nature Medicine · May 1, 2020Peer-reviewedGenomics