Alexander Gräwe

DIALECT enables synthetic cells to communicate with mammalian cells via DNA-programmed ligand release and engineered receptors, achieving specific signaling and logic gate functions.

This paper introduces a method to create homogeneous antibody-DNA conjugates using unmodified oligonucleotides and photo-crosslinkable protein G-HUH endonuclease fusion proteins, achieving 1:1 stoichiometry.

This paper introduces a reversible particle nanoswitch for continuous protein monitoring at picomolar concentrations with automated calibration, achieving accurate long-term measurements.

This paper introduces GLOVID, a biosensor platform that detects intact respiratory viruses by reconstituting split luciferase, achieving ultrasensitive detection of influenza A and RSV.