Christophe Bernard

The paper shows that different biophysical parameters can produce equivalent bifurcation sequences in neuronal models, revealing degeneracy in neuronal dynamics.

The paper analyzes seizure dynamics in epileptic mice, finding structured, animal-specific trajectories and circadian modulation in seizure microstructure.

The paper investigates how extracellular K+ dynamics in mouse hippocampal astrocytes vary by dorsoventral region and circadian time, revealing regional and temporal differences in K+ buffering capacity.

The paper develops a minimal mathematical model to study degeneracy in astrocytic potassium buffering, revealing robustness through local and long-range mechanisms.

This study examines circadian Zbtb14 protein dynamics in the hippocampus of epileptic mice, finding disrupted oscillations and altered gene regulation.

This study shows how local brain manipulations affect global brain dynamics using simulations and experimental data, revealing specific network changes and localization of effects.

This paper introduces a new prosthesis for long-term, near-continuous electrophysiological recordings in rats, achieving high retrieval success rates and improved durability.

The paper shows that during hippocampal ripples, up-states and spindles co-occur in the retrosplenial cortex and predict CA1 slow gamma oscillations, suggesting a role in memory consolidation.

The paper shows that brain timescales dynamically shift between back-to-front and front-to-back gradients based on non-local interactions.

The paper introduces a design template for multiscale cosimulation in neuroscience, enabling integration of cellular and population-level models to enhance computational modeling capabilities.

This paper develops a mean-field model of neuronal populations incorporating ion-exchange mechanisms to simulate brain activity and validate its effects through in vitro experiments.

This paper identifies neuronal cascades as a mechanism underlying resting-state brain dynamics, showing they produce BOLD co-fluctuations and stable brain states in mice and humans.

The paper shows that hippocampal metabolism varies along the dorsoventral axis and over time in control mice, with changes in epilepsy affecting this spatio-temporal pattern.

The paper investigates altered information processing dynamics in experimental epilepsy, finding disrupted substate organization during theta and slow oscillations in specific brain regions.

The paper identifies daily oscillating transcripts in the hippocampus of control and epileptic mice, showing distinct circadian patterns and implications for drug timing.

This study identifies spatially organized neuronal assemblies in the nucleus reuniens during slow oscillations and shows their role in stabilizing prefrontal cortex and hippocampal sequences.

The paper identifies SuML-DG neurons that modulate theta and gamma oscillations in the dentate gyrus during REM sleep and other vigilance states.

This paper introduces a taxonomy of seizure dynamotypes based on bifurcation theory and applies it to EEG data, identifying 16 dynamotypes and their variations across patients.

The paper analyzes dynamic information sharing networks in hippocampus and entorhinal cortex, revealing core-periphery structures that evolve over time and switch between states independently of global oscillatory states.

The paper demonstrates that individual structural connectomes predict functional brain organization in mice, with asymmetry and link weights being key predictors.

The paper shows that early-life caffeine exposure in Tau22 transgenic mice accelerates cognitive deficits linked to Alzheimer's-like pathology.

The paper analyzes single-cell firing patterns in the lateral supramammillary nucleus during hippocampal sharp-wave ripples in anesthetized rats, identifying differences between neurons active during these events and those that are not.

This study examines the effects of individual housing on stress, cognitive, and seizure parameters in rat and mouse epilepsy models, finding increased stress and seizures in singly housed animals.

The paper identifies computing microstates in rat brain regions where specific neurons perform storage and sharing operations, showing dynamic reassignment of functional roles across brain states.

The paper introduces The Virtual Mouse Brain, a platform for simulating whole mouse brain dynamics using connectome data to study health and disease.