Author

Zachary M. Augur

Brigham and Women's HospitalORCID 0000-0001-9664-7498Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Duc Minh DuongiD· 3 shared Nicholas T. SeyfriediD· 3 shared Philip L. De JageriD· 3 shared Tracy L. Young‐PearseiD· 3 shared Cheryl PaniD· 2 shared Courtney R. BenoitiD· 2 shared Gizem TerzioğluiD· 2 shared Hyo LeeiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Duc Minh DuongORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 20, 2025

BAG3 coordinates astrocytic proteostasis of Alzheimer's disease-linked proteins via proteasome, autophagy, and retromer complex interactions

Zachary M. Augur, Garrett M. Fogo, Courtney R. Benoit…·Tracy L. Young‐Pearse

This study identifies BAG3's role in astrocytic proteostasis in Alzheimer's disease by showing its interactions with autophagy, proteasome, and retromer components, and its impact on Aβ clearance.

2 citations

humanscRNA-seq

𝕏 PostBluesky

NeuroscienceGliaPeer-reviewedFeb 3, 2025

Contributions of genetic variation in astrocytes to cell and molecular mechanisms of risk and resilience to late onset Alzheimer's disease

Hyo Lee, Richard V. Pearse, Alexandra M Lish…·Tracy L. Young‐Pearse

The paper uses iPSC-derived astrocytes to study genetic risk factors for Alzheimer's disease, finding concordant molecular changes in both astrocytes and brain tissue.

22 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintFeb 25, 2023

Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1

Hyo Lee, Aimee J. Aylward, Richard V. Pearse…·Tracy L. Young‐Pearse

This study shows that SORL1 loss reduces APOE levels specifically in neurons and astrocytes, linking SORL1 and APOE to Alzheimer's disease risk through distinct pathways.

4 citations

humanbulk RNA-seq

𝕏 PostBluesky