Author

Nils Bessler

Oncode InstituteORCID 0000-0002-0065-3947Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Anne C. RiosiD· 3 shared Raphaël V U CollotiD· 3 shared Anoek ZomeriD· 2 shared Cristian Ruiz-MorenoiD· 2 shared Ellen J. WehrensiD· 2 shared Hendrik G. StunnenbergiD· 2 shared María AlievaiD· 2 shared Mariëtte E.G. KranendonkiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Anne C. RiosORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer-myeloid cell invasive program in pediatric-type diffuse high-grade glioma

Cristian Ruiz-Moreno, Raphaël V U Collot, Thijs J M van den Broek, Ellen J. Wehrens, Nils Bessler, Gitanjali Dharmadhikari, Brigit M. te Pas, Ignacio L. Ibarra, Dennis Serge Metselaar, Mariëtte E.G. Kranendonk, Eelco Wieger Hoving, Jasper van der Lugt, Friso Calkoen, Anoek Zomer, Fabian Theis, , Hendrik G. Stunnenberg

This paper presents an integrative multimodal atlas of pediatric-type diffuse high-grade gliomas, identifying cancer-myeloid cell programs and distinct cancer cell states across multiple patients.

bioRxiv · Jan 25, 2026 · PreprintCancer Biology

De novo H3.3K27M-altered Diffuse Midline Glioma in human brainstem organoids to dissect GD2 CAR T cell function

Nils Bessler, Amber K. L. Wezenaar, Hendrikus CR Ariese, Celina Honhoff, Noëlle Dommann, Ellen J. Wehrens, Cristian Ruiz-Moreno, Thijs J M van den Broek, Raphaël V U Collot, Daan J. Kloosterman, Farid Keramati, Mieke M Roosen, Sam de Blank, Esmée J. van Vliet, Mario Barrera Román, , Anne C. Rios

This paper develops a human brainstem organoid model of H3.3K27M-altered DMG to study GD2 CAR T cell function and identify therapeutic targets.

Nature Cancer · Jan 5, 2026Peer-reviewedCancer Biology

BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

Emilio Rios-Jimenez, Anoek Zomer, Raphaël V U Collot, Mario Barrera Román, Sandra F Archidona, Hendrikus Ariese, Ravian L. van Ineveld, Michiel Kleinnijenhuis, Nils Bessler, Hannah R. Johnson, Caleb A. Dawson, Anne C. Rios, María Alieva

BEHAV3D-TP is a computational framework for analyzing single-cell behavior in tumor microenvironments using intravital microscopy data, revealing migratory behaviors linked to specific TME components in diffuse midline glioma.

eLife · Oct 15, 2025Peer-reviewedCancer Biology