mTORC1 Signaling Inhibition Modulates Mitochondrial Function in Frataxin Deficiency
Madison K Lehmer, Roberto Zoncu
This study shows that inhibiting mTORC1 signaling improves mitochondrial function and cell survival in Friedreichs Ataxia models by altering mitochondrial composition and reducing stress-induced mitophagy.
bioRxiv · Aug 6, 2024 · PreprintCell Biology