Roberto Zoncu

This study identifies PCSK9 as a key determinant of metastatic organ preference in pancreatic cancer by regulating cholesterol acquisition and utilization in liver versus lung environments.

This study identifies AKAP11 as a scaffold linking autophagy to PKA signaling, showing its role in phosphorylation regulation and neuronal homeostasis, with implications for schizophrenia and bipolar disorder.

The paper identifies LyLAP as a key enzyme for lysosomal degradation of transmembrane proteins, showing its role in maintaining endocytic activity and lysosomal stability in pancreatic cancer.

This study shows that inhibiting mTORC1 signaling improves mitochondrial function and cell survival in Friedreichs Ataxia models by altering mitochondrial composition and reducing stress-induced mitophagy.