Author

Fang Hu

University of Hong KongORCID 0000-0003-3092-6034Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:whole-genome sequencing· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Approach:machine learning (classical)· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Jason W.H. WongiD· 3 shared Jayne A. BarbouriD· 3 shared Xiaoqiang ZhuiD· 2 shared Haocheng Yang· 1 shared Jieun OhiD· 1 shared Lauri A. AaltoneniD· 1 shared Michelle W. Wong‐BrowniD· 1 shared Nikola A. BowdeniD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenomics

Jason W.H. WongORCID

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3 papers

Recent·Most cited

Molecular BiologyCell GenomicsPeer-reviewedAug 1, 2024

Global and local redistribution of somatic mutations enable the prediction of functional XPD mutations in bladder cancer

Jayne A. Barbour, Tong Ou, Haocheng Yang…·Jason W.H. Wong

The paper identifies how XPD mutations alter somatic mutation patterns in bladder cancer and develops a machine-learning model to predict pathogenic XPD mutations with 100% accuracy in an independent cohort.

10 citations

humanwhole-genome sequencing

𝕏 PostBluesky

GenomicsbioRxivPreprintNov 18, 2020

Deficiency in DNA mismatch repair of methylation damage is a major mutational process in cancer

Fang Hu, Xiaoqiang Zhu, Jieun Oh…·Jason W.H. Wong

The paper identifies a non-canonical role of DNA mismatch repair (MMR) in repairing methylation damage in non-dividing cells, contributing to mutational signatures in cancer.

1 citation

humanwhole-genome sequencing

𝕏 PostBluesky

GenomicsPLoS GeneticsPeer-reviewedFeb 3, 2020

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer

Fang Hu, Jayne A. Barbour, Rebecca C. Poulos…·Jason W.H. Wong

The paper analyzes POLE exonuclease domain mutants in colorectal cancer, identifying mutation spectra differences and a specific TP53 mutation enrichment.

34 citations

humanwhole-genome sequencing

𝕏 PostBluesky