Jason W.H. Wong

This study reveals how ATRX modulates chromatin by unwrapping nucleosomal DNA through a unique 'pin-like' structure and other features, proposing a 'climbing' mechanism for DNA translocation.

SHINE integrates spatial transcriptomics and metabolomics data to identify microenvironments, outperforming existing methods in segmentation and biomarker co-localization.

The paper identifies NK-like CD8 T-cell expansion and CXCL12+ reticular cell remodeling as markers of azacitidine response in MDS through longitudinal bone marrow profiling.

The paper identifies non-coding variants in CDKN2B that disrupt CTCF binding, reduce CDKN2A expression, and increase melanoma risk in families.

The paper identifies a TNF-α responsive cryptic promoter driving ERVK-7 overexpression in LUAD, revealing cell-type and inflammatory signal-specific regulation.

This paper introduces a new VNS method, i2CS, that selectively activates organ-specific fibers in the vagus nerve, improving selectivity over side effects in swine.

The paper identifies how XPD mutations alter somatic mutation patterns in bladder cancer and develops a machine-learning model to predict pathogenic XPD mutations with 100% accuracy in an independent cohort.

The paper shows that inhibiting VTA dopamine neurons during reward cue presentation prevents sign-tracking behavior, confirming dopamine's role in encoding incentive value.

The paper identifies cell-type-specific regulatory roles of a heptad of transcription factors in human hematopoietic stem and progenitor cells.

LocusMasterTE improves TE expression quantification by integrating long-read and short-read RNA-seq data using an EM algorithm.

The paper evaluates the ability to predict metabolite levels from gene expression in cancer cell lines and finds that gene expression is a poor predictor.

The paper identifies a non-canonical role of DNA mismatch repair (MMR) in repairing methylation damage in non-dividing cells, contributing to mutational signatures in cancer.

The paper analyzes POLE exonuclease domain mutants in colorectal cancer, identifying mutation spectra differences and a specific TP53 mutation enrichment.

The paper identifies mutation-methylation associations in cancer genomes, linking CpG methylation to mutation patterns and driver formation across cancer types.