Nikola A. Bowden

The paper identifies how XPD mutations alter somatic mutation patterns in bladder cancer and develops a machine-learning model to predict pathogenic XPD mutations with 100% accuracy in an independent cohort.

This study shows that hypomethylating agents induce epigenetic and transcriptional heterogeneity in AML cells, with some cells retaining methylation and showing increased self-renewal, and identifies statins as a potential co-treatment to enhance HMA efficacy.