Carles A. Boix

The paper introduces ExRPath and 15ExMPath techniques to expand human brain tissue for nanostructure analysis, revealing amyloid nanoclusters associated with SARS-CoV-2 in COVID-19 patients.

The paper identifies Wnt signaling defects and GSK3b overactivity as regulators of lipid accumulation in APOE4 oligodendrocytes, showing that inhibiting GSK3b reduces lipid droplets and improves myelination.

This study identifies molecular and cellular signatures of cognitive resilience in Alzheimer's disease by integrating multi-omics data from brain tissues.

The paper uses single-nuclei RNA-seq and spatial transcriptomics to analyze gene expression changes in the right atrium of patients with ischemic heart disease, revealing inflammatory microvascular dysfunction and altered tissue composition.

The paper introduces Translatomer, a transformer model that predicts cell-type-specific translation from mRNA and sequence data, identifies disease variants affecting translation, and reveals non-eQTL regulatory mechanisms.

This study identifies ABCA7 loss-of-function variants' impact on phosphatidylcholine metabolism in human neurons and shows CDP-choline can reverse these effects.

The paper evaluates 23 imputation models for cross-cell type epigenomic data, finding quality assessment challenging due to distributional shifts, data availability, and redundant metrics.

The paper identifies that DNA double strand breaks in neurons activate immune pathways, leading to microglia activation in neurodegeneration.

This study analyzes somatic mosaicism in Alzheimer's Dementia using single-cell data, finding increased mutational burden in specific cell types and genes associated with disease processes.