Author

Jialin He

Second Affiliated Hospital of Zhejiang UniversityORCID 0009-0002-7635-596XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:variant effect prediction· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:Ribo-seq· 1

Frequent Co-Authors

Xushen XiongiD· 2 shared Carles A. BoixiD· 1 shared Chengyu LiiD· 1 shared Jianche LiuiD· 1 shared Jingyun LiiD· 1 shared Jiuhong NaniD· 1 shared Ke DingiD· 1 shared Kexuan CheniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioinformatics

Xushen XiongORCID

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2 papers

Recent·Most cited

In-silico modeling and interpretation of RBP binding disentangle m6A-RBP interaction

Jianche Liu, Xinlu Zhu, Yin Yang, Zefeng Xu, Jialin He, Xushen Xiong

The paper introduces TransRBP, a deep learning framework that models RBP binding and m6A interactions, revealing variant-RBP combinations linked to genetic diseases.

bioRxiv · Nov 23, 2024 · PreprintBioinformatics

Deep learning modeling of ribosome profiling reveals regulatory underpinnings of translatome and interprets disease variants

Jialin He, Lei Xiong, Shaohui Shi, Chengyu Li, Kexuan Chen, Qianchen Fang, Jiuhong Nan, Ke Ding, Jingyun Li, Yuanhui Mao, Carles A. Boix, Xinyang Hu, M Kellis, Xushen Xiong

The paper introduces Translatomer, a transformer model that predicts cell-type-specific translation from mRNA and sequence data, identifies disease variants affecting translation, and reveals non-eQTL regulatory mechanisms.

bioRxiv · Feb 26, 2024 · PreprintGenomics