Author

Denise Al Alam

University of California, Los AngelesORCID 0000-0003-3148-7352Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Soula DanopoulosiD· 2 shared Soumyaroop BhattacharyaiD· 2 shared Thomas J. MarianiiD· 2 shared Ana Ivonne Vazquez‐ArmendariziD· 1 shared Andrew McDavidiD· 1 shared Arun LingampallyiD· 1 shared Cameron D. BakeriD· 1 shared Caroline L. CherryiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersGenomics

Soula DanopoulosORCID

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3 papers

Recent·Most cited

Single cell transcriptomic profiling identifies molecular phenotypes of newborn human lung cells

Soumyaroop Bhattacharya, Jacquelyn Myers, Cameron D. Baker, Minzhe Guo, Soula Danopoulos, Jason R. Myers, Gautam Kumar Bandyopadhyay, S. Romas, Heidie L. Huyck, Ravi S. Misra, Jennifer Dutra, Jeanne Holden‐Wiltse, Andrew McDavid, John M. Ashton, Denise Al Alam, , Thomas J. Mariani

The paper uses single-cell RNA sequencing to create a molecular map of newborn human lung cells and identifies cell type-specific developmental states and biomarkers.

Genes · Feb 26, 2024Peer-reviewedGenomics

A Trisomy 21 Lung Cell Atlas

Soumyaroop Bhattacharya, Caroline L. Cherry, Gail H. Deutsch, Ian A. Glass, Thomas J. Mariani, Denise Al Alam, Soula Danopoulos

This study creates a single-cell atlas of prenatal Trisomy 21 lungs, revealing molecular changes linked to early pulmonary complications.

bioRxiv · Mar 30, 2023 · PreprintDevelopmental Biology

Fgfr2b signaling is essential for the maintenance of the alveolar epithelial type 2 lineage during lung homeostasis in mice

Negah Ahmadvand, Arun Lingampally, Farhad Khosravi, Ana Ivonne Vazquez‐Armendariz, Stefano Rivetti, Matthew R. Jones, Jochen Wilhelm, Susanne Herold, Guillermo Barreto, Janine Koepke, Christos Samakovlis, Gianni Carraro, Jin‐San Zhang, Denise Al Alam, Savério Bellusci

This study shows Fgfr2b signaling is essential for maintaining AT2 cells in adult mouse lungs, with IAAPs acting as potential progenitors.

Cellular and Molecular Life Sciences · May 19, 2022Peer-reviewedDevelopmental Biology