Minzhe Guo

GM-CSF Programs Alveolar Macrophages to Maintain Pulmonary Lymphocyte Homeostasis

This study identifies GM-CSF as a regulator of pulmonary lymphocyte homeostasis by controlling alveolar macrophage function and preventing lymphocytosis.

Vessel Organoids Reveal FOXF1 Variant-Specific Regulation of Mesoderm and Capillary Development

The paper uses vessel organoids to study how different FOXF1 variants affect mesoderm and capillary development in humans, showing variant-specific disruptions and potential therapeutic rescue.

Mesothelial Plasticity Specifies a Pleural Immune Circuit that Orchestrates Lung Regeneration

The paper identifies mesothelial cell plasticity as a key determinant of regenerative versus degenerative lung repair by comparing pneumonectomy and chronic lung allograft dysfunction models.

Decoding Lymphangioleiomyomatosis (LAM) Niche Environment via Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics

This study identifies two distinct LAM subtypes and their microenvironmental interactions using multi-omics and spatial transcriptomics, revealing key regulatory networks and potential therapeutic targets.

KLF6 in Pulmonary Hypertension: The Dual Role of Friend and Foe

This study identifies KLF6 as a key driver of endothelial dysfunction in pulmonary arterial hypertension, showing its role in promoting vascular remodelling and angioproliferative lesions.

Isoform-Specific Roles of NTRK2 in Pulmonary Vascular Regeneration

The paper identifies an NTRK2 isoform switch in BPD lungs that impairs endothelial regeneration and shows that restoring full-length NTRK2 mRNA can reverse alveolar damage.

PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function

This study shows PRDM3 and PRDM16 regulate chromatin accessibility to support NKX2-1-driven alveolar epithelial differentiation and function, with loss leading to respiratory failure and lineage infidelity.

APOE-NOTCH Axis Governs Elastogenesis During Human Cardiac Valve Remodeling

The paper identifies a novel APOE+ elastin-producing valve interstitial cell subtype and reveals the APOE-NOTCH signaling axis regulates elastogenesis during human cardiac valve remodeling.

Patho-transcriptomic analysis of invasive mucinous adenocarcinoma of the lung (IMA): comparison with lung adenocarcinoma with signet ring cell features (SRCC)

This study compares the patho-transcriptomic profiles of invasive mucinous adenocarcinoma (IMA) and adenocarcinoma with signet ring cell features (SRCC), identifying distinct and shared gene expression patterns and potential therapeutic targets.

Single cell transcriptomic profiling identifies molecular phenotypes of newborn human lung cells

The paper uses single-cell RNA sequencing to create a molecular map of newborn human lung cells and identifies cell type-specific developmental states and biomarkers.

Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

Guided construction of single cell reference for human and mouse lung

The paper constructs a single-cell reference atlas for human and mouse lung tissues to improve cell type annotation and data integration.

LungMAP Portal Ecosystem: Systems-Level Exploration of the Lung

The paper describes the LungMAP Portal Ecosystem, a centralized resource integrating multi-omics and imaging data across species to enable standardized analysis of lung biology and disease.

PI3K Signaling Specifies Proximal-Distal Fate by Driving a Developmental Gene Regulatory Network in Sox9+ Lung Progenitors

The paper identifies PI3K signaling's role in regulating SOX9+ lung progenitor cell fate through gene regulatory networks using RNA-Seq and ATAC-Seq data.

KMT2D-NOTCH Mediates Coronary Abnormalities in Hypoplastic Left Heart Syndrome

This study identifies KMT2D-NOTCH signaling defects in HLHS coronary artery endothelial cells, showing impaired differentiation and proliferation due to suppressed NOTCH target genes.

Matrix fibroblast function during alveolarization is dependent on GATA6

This study shows that GATA6 is essential for matrix fibroblast function during alveolarization, as its loss impairs alveolarization and disrupts AT1 cell differentiation.

Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates

This study shows that blocking inflammation in preterm primates prevents lung injury, preserving alveolar structure and function similar to chronic lung disease in newborns.

Lung at a Glance: an integrative web toolset of lung ontology, imaging and single cell omics

The paper introduces a web toolset called Lung-at-a-glance to integrate and visualize lung ontology, imaging, and single-cell omics data.

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Across 1,176,683 airway and lung cells from 22 datasets, ACE2 rises with age, in males and in smokers' multiciliated cells, and is lowest in young children.

Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection

The paper uses single nucleus ATAC-seq and RNA-seq to show age-related changes in chromatin accessibility and gene expression linked to SARS-CoV-2 entry genes in human lung cells.