Endoglucanase-2 (Eng2), a conserved immunodominant antigen in dimorphic fungi that elicits immunity and resistance during infection
Uju Joy Okaa, Cleison Ledesma Taira, Lucas dos Santos Dias, Hannah E. Dobson, Gregory C. Kujoth, Althea Campuzano, E. Jane Homan, George R. Thompson, Chiung-Yu Hung, George S. Deepe, Marcel Wüthrich, Bruce S. Klein
This study identifies Eng2 as a conserved antigen in dimorphic fungi that elicits protective immunity and memory T cell responses in mice and humans.
bioRxiv · Jun 23, 2025 · PreprintImmunology