Author

Lucas dos Santos Dias

National Institutes of HealthORCID 0000-0003-2344-1354Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 5 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Bruce S. KleiniD· 4 shared Cleison Ledesma TairaiD· 4 shared Marcel WüthrichiD· 4 shared George R. ThompsoniD· 2 shared Michail S. LionakisiD· 2 shared Uju Joy OkaaiD· 2 shared Xin He· 2 shared Aditya JosyulaiD· 1 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersImmunology

Bruce S. KleinORCID

Mutual co-authors in cluster

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6 papers

Recent·Most cited

MicrobiologybioRxivPreprintJun 16, 2026

An innate immune circuit involving the lectin pathway, complement and lung epithelial cells enforce barrier immunity to inhaled fungal disease

Darin L. Wiesner, Gaurav Bairwa, Desai Prashant…·Bruce S. Klein

DOI 10.64898/2026.06.15.732416

𝕏 PostBluesky

ImmunologymBioPeer-reviewedJun 11, 2026

Combination adjuvants drive long lived plastic Th17 cells that convert to multi-functional Th1 cells and protect mice against fungal infection

Marcel Wüthrich, Uju Joy Okaa, Cleison Ledesma Taira…·Bruce S. Klein

The paper shows that combination adjuvants drive Th17 cells that convert to multi-functional Th1 cells, enhancing antifungal immunity in mice.

2 citationstop 4%

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivApr 23, 2026

Natural Killer Cell Granule Protein (NKG7) promotes the development of vaccine-induced anti-fungal Th1 cells

Marcel Wüthrich, Cleison Ledesma Taira, Lucas dos Santos Dias…·Bruce S. Klein

This study identifies NKG7 as a regulator that promotes anti-fungal Th1 cell development and converts Th17 cells into polyfunctional memory Th1 cells.

DOI 10.1371/journal.ppat.1014187

humanexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintMar 7, 2026

Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency

Eliezer Heller, Lucas dos Santos Dias, Michail S. Lionakis

This study investigates the effects of selective JAK inhibition in AIRE-deficient mice, finding that JAK2 inhibition is most effective in reducing IFN-γ-driven autoimmunity.

DOI 10.64898/2026.03.05.709894

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintJun 23, 2025

Endoglucanase-2 (Eng2), a conserved immunodominant antigen in dimorphic fungi that elicits immunity and resistance during infection

Uju Joy Okaa, Cleison Ledesma Taira, Lucas dos Santos Dias…·Bruce S. Klein

This study identifies Eng2 as a conserved antigen in dimorphic fungi that elicits protective immunity and memory T cell responses in mice and humans.

DOI 10.1101/2025.06.23.661097

𝕏 PostBluesky

ImmunologybioRxivPreprintJan 13, 2025

Microplastics disrupt a cDC1-CD8/NKT regulatory circuit that restrains plasma cell accumulation after injury

Aditya Josyula, Daphna Fertil, Sonakshi Sharma…·Kaitlyn Sadtler

The paper identifies a cDC1-CD8/NKT regulatory circuit that limits plasma cell accumulation after injury, which is disrupted by microplastic contamination.

2 citations

mouseexperimental assay

𝕏 PostBluesky