Structural basis for continuous DNA-end protection during ligation of double-strand breaks in yeast Non-Homologous End-Joining
Sophia Missoury, Claire Tettaravou, Sara Castelli, Amandine Pelletier, Vincent Morin, Paloma F. Varela, Virginie Ropars, Stefano Mattarocci, Pierre Legrand, Mauro Modesti, Stéphane Marcand, Jean‐Baptiste Charbonnier, Marc H. Delarue
This study presents cryo-EM structures of yeast NHEJ complexes, revealing mechanisms for DNA-end protection and ligation without DNA-PKcs.
bioRxiv · Mar 12, 2026 · PreprintMolecular Biology