NeurosciencebioRxivPreprint
Epigenetic regulation of the circadian gene Per1 in the hippocampus mediates age-related changes in memory and synaptic plasticity
Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár…·Marcelo A. Wood
This study shows that HDAC3 restricts long-term memory and synaptic plasticity in aging hippocampus by repressing Per1, a circadian gene, without affecting circadian rhythms.
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