Dina P. Matheos

This paper characterizes the 3xTg-AD mouse model of Alzheimer's Disease across its lifespan and compares it with the 5xFAD model to assess pathology and model drift.

The paper performs a comprehensive phenotypic analysis of the 5xFAD mouse model across its lifespan, identifying novel age-related pathological features.

The paper uses single-cell and nucleus RNA-seq to analyze glial subpopulations in AD mouse models, finding differences in astrocyte activation and microglia subtypes between 3xTg-AD and 5xFAD models.

TALON annotates and counts full-length reads from PacBio or Nanopore in one framework; in mouse brain, 422 genes showed more novel-isoform reads than annotated ones.

The paper identifies PP4-dependent HDAC3 dephosphorylation as a mechanism distinguishing axonal regeneration from regenerative failure in nerve injuries.

This study shows that HDAC3 restricts long-term memory and synaptic plasticity in aging hippocampus by repressing Per1, a circadian gene, without affecting circadian rhythms.

This study shows that HDAC3 negatively regulates habit formation in the dorsal striatum, with distinct roles in the dorsolateral and dorsomedial striatum.