Epigenetic regulation of the circadian gene Per1 in the hippocampus mediates age-related changes in memory and synaptic plasticity
Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Paolo Sassone‐Corsi, Pierre Baldi, Dina P. Matheos, Marcelo A. Wood
This study shows that HDAC3 restricts long-term memory and synaptic plasticity in aging hippocampus by repressing Per1, a circadian gene, without affecting circadian rhythms.
bioRxiv · Apr 13, 2018 · PreprintNeuroscience