Tatsuhisa Tsuboi

Expanding tunable selection in yeast using auxotrophic markers URA3 and TRP1

This paper converts traditional binary auxotrophic markers into tunable selection tools in yeast, enabling quantitative analysis of gene expression through growth outcomes.

A nucleation distance sets the cell size-dependent P-body assembly

The paper investigates how cell size affects P-body assembly in yeast, finding a nucleation distance of 2.2 micrometers that links cell geometry to condensate formation.

PB-scope: Contrastive learning of dynamic processing body formation reveals undefined mechanisms of approved compounds

PB-scope uses deep learning to analyze PB dynamics and identifies drugs affecting JAK signaling pathway.

Gravitational and mechanical forces drive mitochondrial translation

The paper shows that gravity and mechanical forces influence mitochondrial translation by affecting signaling pathways and malonylation of the translational machinery.