Atsushi Higashitani

This study shows microgravity reduces mechanoreceptor gene expression in C. elegans, causing neuromuscular defects and accelerated aging, but physical stimulation in space can reverse these effects.

The paper investigates the interaction between Solo and LARG in response to substrate stiffness and finds that this interaction is required for actin polymerization.

The paper shows that gravity and mechanical forces influence mitochondrial translation by affecting signaling pathways and malonylation of the translational machinery.

The paper uses Pu-seq to map DNA polymerase usage in human cells, revealing Polε synthesizes the leading strand and Pol contributes to lagging strand synthesis, and links transcription to polymerase uncoupling and chromosomal instability.