Brandon Estrem

The paper identifies a sequence motif, SFE, that is necessary and sufficient for generating DNA double-strand breaks and telomere healing during programmed DNA elimination in nematodes.

The paper studies DNA double-strand breaks (DSBs) during nematode programmed DNA elimination, showing that DSBs are processed with end resection and telomere addition, with biased repair on retained ends.

The paper investigates programmed DNA elimination (PDE) in parasitic nematodes, showing how it leads to karyotype changes through chromosome fusion and DNA loss.

This paper establishes Oscheius tipulae as a genetic model for studying programmed DNA elimination (PDE) and identifies conserved motifs and mechanisms involved in DNA loss during embryogenesis.