Author
Harvard UniversityORCID 0000-0003-3262-4160Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Xiangwen Ji, Xueke Bai, Guo Qing He…·Qinghua Cui
The paper evaluates somatic contamination in germline genomes using WES and WGS data from UK Biobank, TCGA, and 1000 Genomes Project, revealing limitations in current filtering methods and the impact of somatic mutations on genetic studies.
Tianxin Liu, Qian Zhu, Kai Yan…·Stuart H. Orkin
The paper shows Matrin3 stabilizes chromatin accessibility and loop-domain interactions, and facilitates YY1-mediated enhancer-promoter interactions during differentiation.
Taku Harada, Yaser Heshmati, Jérémie Kalfon…·Maxim Pimkin
The paper identifies a modular core regulatory circuitry in AML that enforces oncogene expression in KMT2A-rearranged leukemias.
Kai Yan, Stephanos Tsoucas, Shengbao Suo, Guo‐Cheng Yuan
The paper improves a chromatin state annotation method and applies it to 127 human cell types, revealing patterns related to cell origin and 3D chromatin structure.
Kai Yan, Jaclyn Andricovich, Zhouhao Zeng…·Weiqun Peng
This paper introduces Lollipop, a machine-learning framework that predicts CTCF-mediated chromatin interactions using genomic and epigenomic features, outperforming existing methods.