Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops
Taku Harada, Jérémie Kalfon, Monika W. Perez, Kenneth Eagle, Flora Dievenich Braes, Rashad Batley, Yaser Heshmati, Juliana M. Xavier-Ferrucio, Jazmin Ewers, Stuti Mehta, Andrew V. Kossenkov, Jana M. Ellegast, Allyson Bowker, Jayamanna M. Wickramasinghe, Behnam Nabet, , Maxim Pimkin
The paper reconstructs a sparsely interconnected transcriptional hierarchy in leukemia cells stabilized by incoherent feed-forward loops and shows inhibitors disrupt core regulators' programs.
bioRxiv · Mar 13, 2023 · PreprintSystems Biology