Kevin A. Wilkinson

MFF SUMOylation regulates neuronal mitochondrial morphology and facilitates AMPK-induced mitochondrial fragmentation

This study shows that MFF SUMOylation, mediated by AMPK, is essential for neuronal mitochondrial morphology and fragmentation under stress conditions.

Intercellular mitochondrial transfer and transmitophagy in response to protein import dysfunction

The paper investigates intercellular mitochondrial transfer and transmitophagy in response to protein import dysfunction, showing distinct mitochondrial fates and degradation mechanisms.

Disease-associated mutations in GluK2 disrupt compartment-specific regulatory mechanisms controlling kainate receptor membrane trafficking.

This study shows how two disease-associated GluK2 mutations disrupt different aspects of receptor trafficking and signaling in neurons.

Global identification of neuronal and astrocytic integral membrane proteins that require Retromer for their endosomal recycling.

The paper identifies neuronal and astrocytic membrane proteins dependent on Retromer for endosomal recycling, highlighting SNX27-Retromer's role in glutamate transporter trafficking.

Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation.

The paper identifies Retromer as a hub for RAB GTPase regulation through proximity proteomics and biochemical analysis.

SUMO-2/3 modification of PINK1 restrains basal mitophagy through regulation of mitochondrial surveillance

This study identifies SUMO-2/3 modification of PINK1 as a mechanism that suppresses basal mitophagy by regulating mitochondrial surveillance.

The congenital multiple organ malformation syndrome, Ritscher-Schinzel syndrome is an endosomal recyclinopathy

This study identifies RSS as a recyclinopathy caused by dysfunction in the Commander endosomal recycling pathway, linking it to multiple tissue malformations.

Coordinated interplay between palmitoylation, phosphorylation and SUMOylation regulates kainate receptor surface expression.

This study investigates how palmitoylation, phosphorylation, and SUMOylation of GluK2 regulate kainate receptor surface expression through coordinated PTM interactions.

SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression

The paper shows that SGIP1 binding to the H9 domain of CB1R promotes axonal surface expression, which regulates presynaptic responsiveness.

GluK2 Q/R editing regulates kainate receptor signalling to modulate AMPA receptor synaptic expression and plasticity

This study shows that GluK2 Q/R editing affects KAR signaling balance, impacting AMPA receptor expression and synaptic plasticity in mice.

Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

This study shows that sustained kainate receptor activation reduces AMPA receptor surface expression and induces hippocampal long-term depression.

Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2

This study identifies LRFN2 as a new SNX27-dependent cargo that regulates AMPA receptor trafficking and synaptic function, revealing an indirect mechanism for SNX27's role in neurological conditions.

The C-terminal Helix 9 motif regulates cannabinoid receptor type 1 trafficking and surface expression

This study identifies the C-terminal Helix 9 domain of CB1R as critical for its axonal surface polarity, stability, and signaling efficiency.

ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor upscaling in response to suppression of synaptic activity

The paper shows that suppression of synaptic activity reduces ADAR2 levels, leading to decreased GluK2 Q/R editing and increased KAR surface expression.

ADAR2 mediated Q/R editing of GluK2 regulates homeostatic plasticity of kainate receptors

This study shows that ADAR2-mediated Q/R editing of GluK2 regulates homeostatic plasticity of kainate receptors through activity-dependent changes in ADAR2 proteostasis.