Ashley J. Evans

RNA foundation models enable generalizable endometriosis disease classification and stable gene-level interpretation

This paper uses RNA foundation models to improve endometriosis classification across cohorts and identifies stable gene-level predictors.

Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation.

The paper identifies Retromer as a hub for RAB GTPase regulation through proximity proteomics and biochemical analysis.

Coordinated interplay between palmitoylation, phosphorylation and SUMOylation regulates kainate receptor surface expression.

This study investigates how palmitoylation, phosphorylation, and SUMOylation of GluK2 regulate kainate receptor surface expression through coordinated PTM interactions.

Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2

This study identifies LRFN2 as a new SNX27-dependent cargo that regulates AMPA receptor trafficking and synaptic function, revealing an indirect mechanism for SNX27's role in neurological conditions.

The C-terminal Helix 9 motif regulates cannabinoid receptor type 1 trafficking and surface expression

This study identifies the C-terminal Helix 9 domain of CB1R as critical for its axonal surface polarity, stability, and signaling efficiency.

ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor upscaling in response to suppression of synaptic activity

The paper shows that suppression of synaptic activity reduces ADAR2 levels, leading to decreased GluK2 Q/R editing and increased KAR surface expression.

ADAR2 mediated Q/R editing of GluK2 regulates homeostatic plasticity of kainate receptors

This study shows that ADAR2-mediated Q/R editing of GluK2 regulates homeostatic plasticity of kainate receptors through activity-dependent changes in ADAR2 proteostasis.