Frédéric Chaux

The paper measures mutation rates in yeast colonies and finds that double mutations occur at higher rates than expected, suggesting transient mutator phenotypes contribute to genomic instability.

The paper uses long-read sequencing to study genome rearrangements in telomerase mutants of Chlamydomonas reinhardtii, revealing complex subtelomere dynamics and alternative mechanisms for chromosome stability.

The paper develops an optimized protocol to extract high-molecular-weight DNA from Chlamydomonas reinhardtii for long-read sequencing, validated with Oxford Nanopore Technologies.

The paper describes the subtelomere architecture in Chlamydomonas reinhardtii using long-read sequencing and identifies repeated elements and their evolutionary dynamics.