Nicolas Agier

The paper identifies mutational signatures caused by DNA:RNA hybrids in yeast genomes, revealing a common mechanism of genetic instability through repair pathways.

The paper identifies a novel mechanism for autopolyploidization in yeast called SEM, demonstrating triploid and tetraploid formation through postmeiotic endoreplication and mating.

The paper analyzes telomere length distributions in 100 Saccharomyces cerevisiae strains, revealing diversity influenced by ploidy, subtelomere structure, and Y element content.

This study shows that host-shift adaptation in S. eubayanus leads to genomic changes, particularly structural variants, linked to sugar metabolism and host-specific traits.

The paper shows repeated loss of mating-type switching in yeast led to heterothallism, polyploidy, and increased heterozygosity across diverse environments.

The paper identifies a new Saccharomyces species, S. chiloensis sp. nov., using integrative taxonomy methods, showing genetic and reproductive divergence from S. uvarum.

This study identifies structural variants in a domesticated Lachancea cidri yeast strain associated with improved fermentation traits compared to wild isolates.

The paper measures mutation rates in yeast colonies and finds that double mutations occur at higher rates than expected, suggesting transient mutator phenotypes contribute to genomic instability.

The paper uses long-read sequencing to study genome rearrangements in telomerase mutants of Chlamydomonas reinhardtii, revealing complex subtelomere dynamics and alternative mechanisms for chromosome stability.

This paper presents 142 high-quality yeast genomes to improve pangenome understanding, identifying structural variants and complex genomic regions.

The paper develops an optimized protocol to extract high-molecular-weight DNA from Chlamydomonas reinhardtii for long-read sequencing, validated with Oxford Nanopore Technologies.

This study identifies two distinct domestication trajectories in Saccharomyces cerevisiae linked to industrial and sourdough bread-making processes, revealing autotetraploidisation as a driver of divergence.

This paper introduces a CRISPR/Cas9 method to generate precise, markerless translocations in yeast, enabling the study of chromosomal rearrangements' phenotypic effects independent of base substitutions.

The paper redesigns a genomic region for improved Hi-C analysis, revealing insights into homolog pairing and loop formation during meiosis.

This study identifies PtbHLH1a, a bHLH-PAS protein in Phaeodactylum tricornutum, that regulates light-dependent diurnal rhythms, cell cycle, and gene expression, with conserved homologs across diatom species.